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These findings suggest a novel function of Ca M in Fas-mediated apoptosis.

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Computer modeling of the interaction between Ca M and helix 2 of the Fas DD predicted that amino acids, which are important for Fas-Ca M binding, and point mutations of these amino acids caused reduced Fas-Ca M binding.

The interaction between Fas and Ca M is increased ∼2-fold early upon Fas activation (at 30 min) and is decreased to ∼50% of control at 2 h.

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