Non sedating ssris
They have the advantage of ease of dosing and low toxicity in overdose.SSRIs are greatly preferred over the other classes of antidepressants for the treatment of children and adolescents, and these agents are also the first-line medications for late-onset depression, due to their superior tolerability and comparatively more benign safety profile.Research chemists quickly began to explore other derivatives of chlorpromazine.The first TCA reported for the treatment of depression was imipramine, a dibenzazepine analogue of chlorpromazine code-named G22355.
Often, treatment failures are caused not by clinical resistance but by medication noncompliance, inadequate duration of therapy, or inadequate dosing.
Antidepressants can have central and peripheral anticholinergic effects, as well as sedative effects, and can block the active reuptake of norepinephrine (NE), serotonin (5-HT), and dopamine.
SSRIs are metabolized via the cytochrome P-450 system and may have drug interactions on that basis.
I don't think one exist, if one does it's in the approval process, I hear there is one that starts with a v in france ..sure. Are they sedating.i have tried an NRI, an SSRI, and tricyclics.
the first was 'okay' but still sedating and making me tired, the SRI and tricyclics made me so tired, sedated and even ANGRY, it was crazy.